Detailed view of Broncos quarterback Russell Wilson's right hand during a Denver Broncos mini camp at UCHealth Training Center.

Detailed view of Broncos quarterback Russell Wilson’s right hand during a Denver Broncos mini camp at UCHealth Training Center.

USA TODAY Sports

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The lines for week 1 are officially posted and there’s no better time than now to take a look at the chart before there’s any movement. We polled our NFL editors and asked them to offer their best bets for Week 1 of the 2022 NFL season with a brief explanation of their picks.

NFL Week 1 Betting Lines

  • Buffalo Bills at Los Angeles Rams (-1)
  • New Orleans Saints vs. Atlanta Falcons (+4)
  • Indianapolis Colts vs. Houston Texans (+7.5)
  • Jacksonville Jaguars vs. Washington Commanders (-4.0)
  • Philadelphia Eagles vs. Detroit Lions (+4.5)
  • New England Patriots vs. Miami Dolphins (-2.5)
  • San Francisco 49ers vs. Chicago Bears (+6.5)
  • Cleveland Browns vs. Carolina Panthers (+4)
  • Baltimore Ravens vs New York Jets (+5.5)
  • Pittsburgh Steelers at Cincinnati Bengals (-6.0)
  • Green Bay Packers vs. Minnesota Vikings (+1.5)
  • Las Vegas Raiders at Los Angeles Chargers (-4.0)
  • New York Giants vs. Tennessee Titans (-6.5)
  • Kansas City Chiefs at Arizona Cardinals (+3.0)
  • Tampa Bay Buccaneers vs. Dallas Cowboys (+2.5)
  • Denver Broncos vs. Seattle Seahawks (+4.5)

Odds via FanDuel Sportsbook

First NFL bets for week 1

New York Giants +6.5 vs. Tennessee Titans

The good news is that Week 1 presents the Giants’ best chance of having a healthy team. And for the Titans, Derrick Henry has averaged just 71 rushing yards in his last four season openers because he’s been a little slow. They also have a whole new starting group of WRs and TEs, so last year’s AFC No.1 seed will struggle to cover the line as she builds her identity.

New Orleans Saints -4 vs. Atlanta Falcons

Neither team was particularly impressive in 2021, but at least for New Orleans injuries played a major role. The Saints are entering a new era after Sean Payton, and while they may not be Super Bowl contenders, the roster is much deeper and more talented than the Marcus Mariota-led Falcons. With Chris Olave in the fold, Michael Thomas back in the mix and Jameis Winston healthy, the Saints – who beat Green Bay 38-3 in Week 1 last season – should come away 1-0.

Detroit Lions +4.5 vs. Philadelphia Eagles

It was one of our biggest missed bets last year, as we thought the Lions would at least stay close at home against an uneven Eagles side to see Detroit tie it 44-6. They catch 4.5 at home this time around. We’re keeping an eye on this one as we could see public money pouring into Philadelphia in light of the AJ Brown trade fueling expectations for this team. We might see the line go up to 5.0 or even 5.5, so the best time to lock this one in might be during the summer. We think the Lions will be tougher in Year 2 under Dan Campbell and open the season with a narrow loss to the Eagles.

Denver Broncos Moneyline (-205) vs. Seattle Seahawks

We know this will be an emotional return for Russell Wilson, and the Seahawks crowd will be absolutely wild. But we’d bet the 12th Man’s enthusiasm would wane after the 13th straight handoff called by Pete Carroll, resulting in another 3-and-out. Seriously, the Seahawks might have one of the worst rosters in the league, and that’s before we discuss the starting quarterback conundrum of Drew Lock or Geno Smith. Maybe the Seahawks can stay in the number (+4.5), but we don’t think they can win this contest.

Denver Broncos (-4.5) vs. Seattle Seahawks

Russell Wilson making his Broncos debut in Seattle against his former team is obviously a compelling matchup, and we don’t expect him to disappoint surrounded by a solid supporting cast. Meanwhile, the Seahawks are still figuring out their QB situation and whoever they deploy in Week 1 will be no match for Wilson & Co.

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